WebJul 3, 2024 · BTG3 is downregulated CRC cell lines and patient tumor samples We first examined the expression levels of BTG3 in human normal colorectal cell line CCD-18Co and two CRC cell lines SW480 and HT29. As shown in Fig. 1 a, BTG3 mRNA levels in the two CRC cell lines were decreased compared to CCD-18Co. WebCyclin-dependent kinase inhibitor 1B (CDKN1B) was identified as a direct target of negative regulation by miR-222-3p in NP cells, and expression of miR-222-3p was found to be negatively correlated with that of CDKN1B in intervertebral disc degeneration tissue.
BTG3 - Wikipedia
WebJul 5, 2024 · BTG3 is the direct target of MIR106A-5p and correlates with poor prognosis in head and neck cancer. Autophagy-related targets of MIR106A-5p were identified using four common bioinformatics tools to generate a pool of predicted candidate genes (Figure 5A,B). Detailed information of the target-gene scan is provided in Table S2. WebOct 22, 2016 · BTG3 presents a third example of this mode of action: BTG3 can interact with E2F1, a transcription factor important for S-phase entry and cell cycle progression. BTG3 binds E2F1 through its N-terminal region, which, in this case, inhibits DNA binding of the E2F1, thereby reducing the overall transcription rate of E2F1-responsive promoters … ltts annual revenue
The function of BTG3 in colorectal cancer cells and its …
WebTranslation of CDKN1B reaches its maximum during quiescence and early G1. Translation is regulated by polypyrimidine tract-binding protein(PTB), ELAVL1, ELAVL4, and microRNAs. PTB acts by binding … WebNov 29, 2024 · PTEN and CDKN1B were significantly downregulated in human and mouse PCa samples, and CDKN1B expression correlated positively with PTEN expression. PTEN overexpression significantly inhibited cell migration and cell-cycle progression and promoted apoptosis in PCa cells by decreasing Ccnd1 expression and increasing that of Cdkn1b. WebMar 20, 2024 · Here we show that genetic deletion of Cdkn1b in ACI rats susceptible to estrogen-induced mammary tumors decreases the relative fraction of Cd49b+ luminal progenitors identifying p27 as a key regulator of the proliferation and pool size of these cells. Progesterone, acting via the progesterone receptor (Pr), is an important regulator of … lttp waterfall of wishing