Epcam biology
WebEpCAM-associated functions relate to cell-cell adhesion, proliferation, maintenance of a pluripotent state, regulation of differentiation, migration, and invasion. These functions can be conferred by the full-length protein and/or EpCAM-derived fragments, which are generated upon regulated intramembrane proteolysis. WebEpCAM is a transmembrane glycoprotein that is a member of the cell adhesion molecule (CAM) family of proteins. This marker is expressed by normal epithelial cells and has been found to be expressed in up to 70% of all primary carcinoma tumor types ( Went et al., 2004 ). EpCAM has been utilized as a tool for CTC enrichment, as epithelial cells ...
Epcam biology
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WebMay 21, 2024 · Abstract. Epithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein primarily known to mediate homotypic cell contacts in epithelia tissues. Because EpCAM expression is limited to normal and malignant epithelia, it has been used as diagnostic marker for the detection of carcinoma cells in mesenchymal organs such … WebAug 7, 2014 · EpCAM is expressed on Clara, ATII, and even potentially on tumor-initiating cells ( 20 – 23 ). Moreover, EpCAM, which can be used to isolate mouse lung epithelial cells ( 20 – 22 ), is overexpressed in lung adenocarcinoma ( 24 ), and is being studied as a target for cancer therapy ( 25 ).
WebOct 25, 2010 · EpCAM has been long known as a tumor-associated antigen highly expressed in a variety of carcinomas (Koprowski et al., 1979).It is used as a marker for aggressive tumors, and has been considered as a potential target for immunotherapy (Osta et al., 2004).In human and mouse, EpCAM is expressed in embryonic epithelia, but the … WebMay 31, 2024 · EpCAM (CD326) is a conserved type I transmembrane glycoprotein of 35 kDa expressed on epithelial cells of higher eukaryotes. It was initially discovered as a …
WebAug 5, 2024 · The biology of EpCAM and its role are not completely understood but evidence suggests that the expression of this epithelial cell-surface protein is crucial for metastasis-competent CTCs and may not be lost completely during the epithelial-to-mesenchymal transition. In this review, we summarize the most significant advantages … WebEpCAM: structure and function in health and disease. Injection of tumor cells in mice more than 30 years ago resulted in the discovery of an epithelial antigen, later defined as a cell adhesion molecule (EpCAM). Although EpCAM has since evoked significant interest as a target in cancer therapy, mechanistic insights on the functions of this ...
WebJul 17, 2015 · EpCAM expressing circulating tumor cells, detected by CellSearch, are predictive of short survival in several cancers and may serve as a liquid biopsy to guide therapy. Here we investigate the ...
WebNov 13, 2024 · Epithelial cell adhesion molecule (EpCAM) is the most frequently expressed tumor-associated antigen; it is overexpressed in the majority of human … is filthy frank racistWebMay 12, 2024 · EpCAM (Epithelial cell adhesion molecule) is often dysregulated in epithelial cancers. Prior studies implicate EpCAM in the regulation of oncogenic signaling … rys curbingWebJan 11, 2009 · Our finding that EpCAM is a potent signal transducer that uses components of the Wnt pathway, with a proven significance for tumour development and cell renewal … rys law officesWebAug 1, 2013 · EpCAM is a cell surface glycoprotein of approximately 40 kDa (detailed below) that is highly expressed in epithelial cancers and at lower levels in normal simple … rys handyman \u0026 craftsmanWebAbstract: The epithelial cell adhesion molecule (EpCAM, CD326) is a glycoprotein of ∼40 kd that was originally identified as a marker for carcinoma, attributable to its high expression on rapidly proliferating tumors of epithelial origin. Normal epithelia express EpCAM at a variable but generally lower level than carcinoma cells. In early studies, EpCAM was … rys fashionWebMay 21, 2024 · Epithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein primarily known to mediate homotypic cell contacts in epithelia tissues. Because EpCAM … rys law groupWebJan 6, 2024 · In this perspective, we thought of investigating epithelial cell adhesion molecule (EpCAM) as a potential molecule. EpCAM is a CSC surface marker that was … is filthy frank still alive